We've had an extra bad season for allergies, and even though Quinn is on apoquel she lost bum/belly hair and still shakes her head and gets mucky eyes on bad days. Otherwise it's done pretty well for her. I spoke to a vet (not ours) about cytopoint, and she said that some dogs do well on both apoquel and cytopoint and others only get relief from one (the other doesn't work). In terms of price, cytopoint is cheaper for smaller dogs, but once you start hitting the 60lb+ size dog, the cost is usually the same or more expensive. She also said that in bad allergy seasons, some dogs on cytopoint need a few does of apoquel on top to manage the flare. She mentioned there are very few side effects of either, and they are both treated in the body the same way (not like one impacts organs and the other doesn't) - so very similar overall. Anyway, we're finishing this year on apoquel and will talk to my regular vet in the spring to get her thoughts. Hope all these itchy labs get some relief!